Endocrine Abstracts

Growth hormone (GH) acts chronically to decrease adiposity, at least in part by the inhibition of lipogenesis. One or more of the twelve isoforms of Protein kinase C (PKC) may be involved in this chronic effect of GH on lipogenesis in adipocytes.Two approaches were adopted to examine the role of PKC isoforms in GH signalling. The first method involved maintaining explants of Finn/Dorset sheep adipose tissue with insulin, GH or a combination of both, for ...